DES Daughters are defined as women born between 1938 and 1971 who were exposed to DES before birth (in the womb). Animal studies don’t conclusively show any DES-related problems by the third generation. There is no need for medication or any other treatment. How likely am I to have problems with fertility if I was exposed to DES? DES was commonly prescribed to women who had a history of pregnancy problems such as bleeding, miscarriages, premature births, stillbirths or diabetes. The activated link is defined as Active Tab. DES daughters have a slightly increased risk of infertility. In this publication, recommendations regarding pelvic examinations for DES Daughters were similar to those recommended for unexposed women.
Some evidence suggests the sons of prenatally DES-exposed women might have an increased risk of hypospadias, but other studies suggest the increase in risk might not be as great as once thought.
Many of the risk factors associated with DES exposure during pregnancy are preventable or treatable if you take action. DES daughters should receive DES examinations annually.  Reinisch cited several cases of "male feminization" among prenatally DES-exposed males.
However, some DES Daughters experienced health problems as a result of reproductive tract abnormalities. The most recent study of infertility among DES Daughters reported that 24% had never become pregnant, compared with 18% of unexposed women. Reasons for DES-related infertility vary. DES Sons DES Exposure can have a Trans-Generational Effect.
CCA of the vagina and cervix is treatable when detected early. Although all women should have good prenatal care, it is particularly important for DES Daughters. Even if a DES daughter doesn’t have any obvious health problems, she still needs special healthcare. the pill – the combined pill contains oestrogen, but there are no reported problems specific to DES, other hormone treatments such as Depo-Provera injections and the high-hormone-dose ‘morning after pill’ – these may be used if appropriate and necessary, the ‘mini-pill’ (progestogen only) – there are no problems with DES, ectopic pregnancy – a serious condition where the fertilised egg lodges in a fallopian tube instead of in the uterine wall, miscarriage – an incompetent (weak) cervix can cause a miscarriage in both the first and second trimesters (the first or second three months of pregnancy), premature labour – caused by an incompetent cervix.
Persons with disabilities having difficulty accessing the information on this page may contact email@example.com for assistance. The following information provides more detail about each of these health problems. NIH study followed daughters of women given diethylstilbestrol during pregnancy and found increased fertility problems and cancer risks. What can I do as a DES Daughter to protect my health during pregnancy? The cancer risks for exposed daughters, as well as sons, are continually being studied to determine if they differ from an unexposed population. In this section, you will find the health risks associated with DES and steps you can to take protect your health and the health of your family. Still, most don’t have problems becoming pregnant. After that, the drug was taken off the market. Many doctors recommend DES Daughters have regular, thorough exams every year. Comparison of Full-term Delivery and Miscarriage Rates for First Pregnancies of DES-Exposed Women vs. Unexposed Women*, Three Possible Sites of an Ectopic Pregnancy in DES Daughters, Infertility Rates for DES Daughters vs. Unexposed Women* Some studies have shown that up to one third of DES Daughters have had some form of reproductive tract abnormality of the cervix, uterus, or fallopian tubes, including vaginal adenosis or cervical changes (such as collars, hoods, septae, and cockscombs) (Jeffries, 1984; Herbst, 1984). DES Sons were slightly more likely to be left-handed than unexposed men (14% vs. 11%, respectively).
Although DES-exposed daughters have about 40 times the risk of developing CCA than unexposed women, CCA is still a rare disease, occurring in 1 in 1,000 DES-exposed daughters. Diethylstilbestrol (DES), a synthetic nonsteroidal estrogen which was previously used clinically to support pregnancy, has been linked to a variety of long-term adverse effects in women who were treated with it during pregnancy and in their offspring. Special healthcare for DES mothers includes: If you are a man whose mother took DES while she was pregnant with you, you are a DES son.  Daughters with prenatal exposure to DES may also have an increased risk of uterine fibroids, and incompetent cervix in adulthood. There is no reason to believe that children born from DES daughters or sons will be affected. Persons with disabilities having difficulty accessing the information on this page may contact firstname.lastname@example.org for assistance.  Kaplan published the first-known medical study (1959) of intersex condition in a male prenatally-exposed to DES. I'm in my 40s. Could you be one of their daughters who was exposed to DES? if you have experienced infertility, a hysterosalpingogram, which is an X-ray that can check for structural differences and physical alterations in your upper genital tract. This helps the doctor find adenosis (an abnormal growth of glandular tissue that is not cancer) or other abnormal tissue. April 2018. About the National Institutes of Health (NIH): NIH, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services.
DES Daughters and Sons study. What should I expect from my health care provider in terms of detecting and monitoring CCA of the vagina and cervix? The so-called “Third Generation DES Daughter” is just now beginning to reach the age when relevant health problems like reproductive disorders can be studied, so it is unclear whether the risks carry on in the offspring of original DES daughters. DES daughters have a slightly higher risk of certain pregnancy complications, including: As DES exposure ceased in 1971, issues around pregnancy are becoming rare.
With tools, information and recommendations tailored to you, it’s your personal and secure health dashboard. DES Daughters are all the women born between 1938 and 1978 who have been exposed in utero to the anti miscarriage drug and man-made estrogen Diethylstilbestrol (or DES in short) . You can have a medication abortion up to nine weeks of pregnancy. Discuss with your doctor which tests are appropriate for you and when you should have them. You should have a special DES check-up every year, along with annual clinical breast examination and mammography, once you have reached 40 years of age. If your mother took DES while she was pregnant with you, then you are a DES daughter or DES son.
Oestrogen is one of the female sex hormones that regulates the menstrual cycle.
The so-called “Third Generation DES Daughter” is just now beginning to reach the age when relevant health problems like reproductive disorders can be studied, so it is unclear whether the risks carry on in the offspring of original DES daughters. Please view the Updated Bibliographies on the A woman may need a lot of tests and treatments, and extended hospital stays. These anomalies contribute to an increased risk of infertility and adverse pregnancy outcomes in prenatally DES-exposed daughters. Links to more detailed information about DES are provided at the bottom of the page. They live in the U.S.A., Canada, Australia, Europe and all corners of the world where … Everyone who was exposed to DES needs special medical care, even if they don’t have any obvious health problems. , DES gained notoriety when it was shown to cause a rare vaginal tumor in girls and young women who had been exposed to this drug in utero. The National Cancer Institute (NCI) published a description of appropriate pelvic examinations for DES Daughters. Third-generation women should be examined carefully for presence of DES-associated changes.
So far, research has shown no decreased fertility for these men, even with testicular abnormalities. However, health care providers should monitor all DES-related abnormalities for changes over time (Kaufman,1995). To learn more about the increased health risks for DES Daughters, refer to Recent DES Research and DES Bibliography.
However, it’s important to note you don’t have to be exposed to DES to have these health problems. Reproductive system - female, Reproductive system - female - Female reproductive system explained, Female genital cutting or circumcision (FGC).  This research has centered on a long-standing question of whether prenatal exposure to DES in offspring of mothers who were prescribed DES may have included sexual orientation and gender-related behavioral effects and physical intersex conditions.
Sometimes, vaginal adenosis can be misdiagnosed as CIN. National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, U.S. Department of Health and Human Services, U.S. Department of Health & Human Services, NIH Institute and Center Contact Information, Get the latest public health information from CDC », Get the latest research information from NIH », NIH staff guidance on coronavirus (NIH Only) », http://www.cancer.gov/cancertopics/factsheet/Risk/DES. (See table below for complete list of increased risks.) As a result, the physical abnormalities that affect DES daughters and sons may affect their children as well.
This page has been produced in consultation with and approved by: Treatment for infertility depends on the cause. Are women who were prescribed DES while pregnant at an increased risk for CCA of the vagina and cervix? The State of Victoria and the Department of Health & Human Services shall not bear any liability for reliance by any user on the materials contained on this website. You should have a special DES check-up every year, along with annual clinical breast examination and mammography, once you have reached 40 years of age. Research has confirmed that DES Daughters are at an increased risk for: Information Resources for DES Third Generation, Although scientists have answered many questions about health risks associated with exposure to DES, questions remain about, For information on how such research was conducted, see, Steps You Can Take to Protect Your Health and the Health of Your Family for DES Daughters, potential health risks and related concerns, Continued Follow-Up of Pregnancy Outcomes, Infertility Among Women Exposed Prenatally, Incidence of Squamous Neoplasia of the Cervix and Vagina, Women Who Were Prescribed DES
Influenza - Dr Brett Sutton & Prof Kanta Subbarao, Trauma - Anne Leadbeater OAM & Dr Rob Gordon, Back to Studies of the third generation are important because DES might be associated with epigenetic changes, which involve changes to the way genes behave (not involving the DNA itself) that may be heritable from one generation to another. CCA of the vagina and cervix occurs more frequently in DES Daughters than in women not exposed to DES. Diethylstilboestrol (DES) was a medication commonly prescribed to prevent miscarriage, between 1946 and 1971 in Australia. Welcome to the portion of CDC's DES Update for DES Daughters. The risk is virtually non-existent among premenopausal women not exposed to DES. This study is also the first to estimate the cumulative proportion of all DES-exposed women who developed these conditions because of their exposure.